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Post 1945: a plague of profitable but destructive chemicals

14 Sep

2010 research findings: 34% of UK cancers in 2010 (106,845) were linked to smoking and alcohol and one in 25 cancers is linked to a person’s job – other causes included exposure to chemicals. The percentages may well have risen. Pollution is one of many factors thought to be responsible for rising rates of allergy.

Despite this knowledge, harmful substances are freely sold in order to enrich a few and any attempt to change this is met with powerful resistance which influences most politicians.

Richard Bruce sent a link to this parliamentary debate opened by the Countess of Mar, a doughty campaigner on behalf of farmers, whose health seriously deteriorated after being compelled by government to use organophosphate sheep dip. Lord Blyth referred to Richard’s experience, but a fuller account is given on his website.

Agriculture: Health & Safety Responsibilities

6 Feb 1996: Column 183

The Countess of Mar rose to ask Her Majesty’s Government what are the statutory duties of the Health and Safety Executive and the Minister of Agriculture, Fisheries and Food to ensure that employers and employees carrying out exclusively agricultural operations are kept informed of, and adequately advised on, matters relating to health and safety.

The noble Countess said: In asking the Question standing in my name on the Order Paper, I declare an interest. I have been exposed to organophosphate sheep dip and believe that I suffer chronic ill health as a result.

Some of the points made in the seven page report:

  1. In 1951, Solly Zuckerman, later Lord Zuckerman, chaired a working party which investigated the health effects on workers using dinitro and organophosphorus compounds in agricultural sprays
  2. It found that repeated low level exposures could result in chronic effects on human health
  3. and recommended simplifying labelling and including the words “Deadly poison” in large letters on containers.
  4. But not until 1994 were manufacturers required to put a skull-and-crossbones symbol on OP sheep dip containers to warn of toxicity.
  5. MAFF introduced national dipping orders in 1976
  6. The orders were rescinded in 1992
  7. GPs, untrained in chemical toxicology, used irrelevant tests & many decided that these patients’ symptoms were psychosomatic.
  8. Effective tests were not recommended by the HSE to GPs and consultants.
  9. The Health and Safety Commission did not consider it appropriate to advise and inform farmers of the inherent dangers of these substances.
  10. The Health and Safety Executive actively suppressed a 1990 field research project.
  11. Internationally research published in the Lancet in May 1995 found damage to farmers and that there was a dose relationship.
  12. Veterinary Products Committee rejected these research findings.
  13. The Countess of Mar asked the Minister how many members of the VPC had the relevant neurobehavioural expertise to assess this research. (Ed: an undated account VPC Members Specialisms and Biographical Details Indicates that none had this expertise, though Dr Karin Burnett had studied several aspects of toxicology).
  14. OPs are said to be too toxic to test on humans and maximum levels of exposure are arbitrarily set.
  15. T.C. Marrs, senior medical officer at the Department of Health, adviser to Ministers and government committees, said at a meeting of farmers in October 1991, “You don’t have to convince me there is long-term damage. I know it”, but did not inform ministers.
  16. Though the National Poisons Unit (NPU) at Guy’s Hospital confirmed that Richard Bruce had been poisoned by organophosphates and this was reported to the HSE, their inspectors did not visit Mr. Bruce or the farm where he worked to investigate the incident.
  17. Lord Blyth asked: How serious does an incident have to be before it is thoroughly investigated? What powers do health and safety inspectors and EMAS doctors have to inspect premises and obtain other evidence?
  18. The NPU withdrew the diagnosis of OP poisoning in a letter to the HSE, copied to Mr. Bruce’s GP on 2nd December 1994, but confirmed the diagnosis to the Benefits Agency in a letter of the same date.
  19. Lord Beaumont cited an Australian case with damages awarded in a court of law and recommended that OP sheep dips be classified as prescription products until the results of the Government’s delayed researches are known.

Baroness Turner said “It is clear from the information received from a number of sources that much needs to be done to improve health and safety standards in this vital industry. Many in it are suffering the effects of pesticide poisoning, and many are dying as a result.

 

The report may be read here.

 

 

 

 

 

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BBC & Nuffield Trust: Merck’s MMR more convenient for working mothers

20 Aug

 

Health experts are particularly concerned about the UK’s 87% uptake of the second MMR vaccination, which is far below the WHO’s 95% goal.

A remedy?

Some doctors have refused to administer the MMR vaccine and Dr Michael Jarmulowicz (FRCPath, MBBS) seeks a compromise, writing in the BMJ:

“What I find puzzling is the adamant refusal of the authorities to facilitate the availability of the single measles vaccine, to the point that the Department of Health has banned its use within the NHS. How does this fit with the growing acceptance of patient autonomy and patient choice? . . .

“Other countries with equivalent medical and ethical standards make them freely available.”

Meanwhile Merck’s influence increases as its profits soar, giving $1,481,549 during the US presidential 2018 Election, according to the Center for Responsive Politics.

A new advantage of the MMR vaccine was heard on Radio 4 or 5 Live this morning (19.8.19). Extensive ‘listening again’ failed to find the precise time and location, but It was stated at some length that the MMR vaccine was more convenient for working mothers as they would only need to attend one appointment.

This ‘convenience’ factor was also traced to the website of the Nuffield Trust:

“The availability of a single, combined vaccination may have simplified the childhood vaccination schedule for children and parents.”

Mothers for whom convenience is a priority could continue to enable their children to have the MMR and those who have seen or heard of adverse effects could thankfully return to the earlier practice.

For wider coverage, as Dr Jarmulowicz suggests, “the medical profession should support a parent’s wish for single dose vaccine, however irrational the establishment might view that wish”.

 

 

 

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Pakistan fends off cultivation of GM corn: Jan. – May 2019

30 May

 JANUARY

The News reported that the Pakistan Agriculture Research Council (PARC) called a meeting of Variety Evaluation Committee (VAC) to seek approval for the commercial farming of genetically modified corn varieties developed by multinational seed companies.

The Federal Minister for National Food Security Sahibzada Mehboob Sultan asked for a cancellation of meeting, saying that this was due to the request of Faisalabad Agriculture University as its team was not ready to show up.

Some stakeholders in the seed business strongly opposed the introduction of genetically modified corn’s commercial cultivation for several reasons:

  • it would increase the cost of farming for farmers due to high royalty fees,
  • it would lead to contamination of local germplasm, particularly in maize, which is a wind pollinated crop,
  • it would have an adverse effect on the investment in locally developed hybrid varieties and discourage local production and research and development in seed business and
  • Pakistan would not be able to export GM products to a wide range of GM-free regions and countries.

They said Pakistan’s per hectare production of corn was already showing an upward trend and with five tons per hectare output of corn hybrids, Pakistan was already ahead of several countries that allowed genetically modified corn. “We are sufficiently meeting our needs of corn through local production and there is no need to experiment with genetically modified organisms, which have several proven issues,” sources said.

FEBRUARY

The Technology Times reported that Pakistan Kissan Mazdoor Tehreek (PKMT) – an alliance of small and landless farmers including women farmers – fully support the position of the Ministry of National Food Security & Research which has distanced itself from going ahead with approval of genetically modified maize in Pakistan by intervening to cancel the VAV meeting in January. PKMT reiterates their demand for a moratorium on genetically modified seeds and foods in the country as it violates farmers’ collective rights to seed.

They stress that the recent lawsuit against Monsanto won by a USA citizen suffering from cancer due to the company’s herbicide Roundup Ready clearly shows the critical health hazard to Pakistani famers who will be forced to use the herbicide along with GM seeds and add that in India, Monsanto’s Bt Cotton has failed drastically; and the story is no different in Pakistan.

For many years, they add, ‘the company’ (Monsanto?) has been lobbying for commercial use of GM maize; which – if approved – will cross-pollinate and rapidly destroy the local maize seed varieties.  Pakistan’s per hectare production of maize was already showing an upward trend that is already ahead of many countries that are using genetically modified maize.

The News reports that – despite strong opposition from farmers, local seed companies, officials and experts of agriculture – multinational companies have increased efforts to get genetically modified (GM) maize registered at the Variety Evaluation Committee (VEC) and start its production in the country.

MARCH

In order to create awareness among journalists about science-related communication, the Lahore chapter of Pakistan Biotechnology Information Center and The International Service for the Acquisition of Agri-biotech Applications (ISAAA) organised a one-day workshop at the Forman Christian College University (FCCU) Lahore on March 3, 2019.

Pakistan Today reports that, during the workshop, Malaysian Biotechnology Information Center (MABIC) Executive Director Dr Mahaletchumy Arujanan gave a brief presentation on biotechnology, Genetic Modification (GM) Technology and the industrial challenges.

FCCU Dean of Postgraduate studies Dr Kauser A Malik told the audience of science writers and journalists that they could play an important role in informing the public about scientific and technological developments by bridging the gap between the common person and scientist, ensuring the ‘formulation of appropriate government policies conducive to the development of science in the country’.

APRIL

Business Recorder published an interview in two parts with a team from CropLife Pakistan Association, an association of multi-national biotech firms working on seed technology in the country, currently advocating the introduction of Genetically Modified seeds, specifically GM maize. Part 1 – focussing on developing an understanding of the science behind GMOs – may be read here. A few days later the second part was published, focussing on the environmental safety and regulatory aspects.

MAY

Representatives of seed companies warned that Pakistan will not be able to export its products to many regions and countries in Europe and Africa. A case in point follows:

Bulgaria, which told the European Union in 2015 that it was to ban the cultivation of crops with genetically modified organisms (GMOs), attended the second meeting of Pakistan-Bulgaria Inter-Ministerial Commission. On Monday 20th May, the Bulgarian Minister for Economy, Liliya Ivanove Ivanove, stated that Bulgaria is looking forward to extensive cooperation in the field of agriculture including sustainable imports of cotton and rice from Pakistan.

But USDA is undeterred: Dawn reports that the Foreign Agricultural Service of the United States Department of Agriculture (USDA) said future collaborative projects between the US and Pakistan include using American GM soybean feed in poultry, fish farming and dairy industries, introducing genetically-engineered maize and working with various government departments to develop uniform food safety standards.

 

 

 

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MMR: why not allow the single vaccine option, in use elsewhere and widely accepted in ‘60s & ‘70s Britain?

30 Apr

 

As Dr Michael Jarmulowicz (FRCPath, MBBS) wrote in the BMJ:

“What I find puzzling is the adamant refusal of the authorities to facilitate the availability of the single measles vaccine, to the point that the Department of Health has banned its use within the NHS. How does this fit with the growing acceptance of patient autonomy and patient
choice? . . .

“Other countries with equivalent medical and ethical standards make them freely available.”

Other countries with equivalent medical and ethical standards do indeed make single vaccines freely available – indeed, Japan, a country with an excellent child health record, completely stopped using the MMR vaccine in 1993 after 1.8 million children had been given two types of MMR and a record number developed non-viral meningitis and other adverse reactions

The Merck measles, mumps and rubella (MMR) vaccine is a mixture of live weakened viruses of the three diseases. The first dose is generally given to children around 9 to 15 months of age and a second dose at 15 months to 6 years of age, with at least 4 weeks between the doses, according to PubMed (US government document – though the country’s National Center for Biotechnology Information (Centers for Disease Control and Prevention) states that the vaccine is only licensed for use in children who are 12 months old.

The scientific argument for immunising infants against measles is to establish a good herd immunity, protecting unvaccinated babies, children and adults who could not be given the vaccination.

Doctors and parents are urged to acquire and carefully read the information leaflets relating to whatever vaccine they are considering and an online search of medical journals finds material which would make a thoughtful parent pause before agreeing to have their baby injected with the MMR vaccine.

The World Health Organisation (a UN affiliated body) reports that Live Attenuated Vaccines (LAVs) raise some general safety and stability concerns and lists six. A snapshot of the measles section follows:

Mass measles immunization campaigns – reporting and investigating adverse events following Immunization – notes that seizure risk is age-dependent, and lower for children over six years, who are unlikely to have febrile seizures. Allergies (especially to gelatine) and general illhealth is a contraindication to vaccination with MMR vaccine.

The most common programme error is an infection as a result of non-sterile injection. The infection can manifest as a local reaction (e.g., suppuration, abscess), systemic effect (e.g., sepsis or toxic shock syndrome), or blood-borne virus infection (e.g., HIV, hepatitis B).

Establishing a profitable monopoly

In the U.S. more than a million dollars has been paid in compensation over the last ten years to parents alleging their children were harmed by the MMR jab, Merck and Co USA. Despite this, the manufacturers of Mumpsvax (Jeryl Lynn strain) announced in January 2010 that it would no longer provide mumps vaccines as single doses. The single dose rubella vaccine has also been halted. Single measles vaccines and a combined measles/rubella vaccine are still available.

Prolonged legal action in its tenth year against Merck, the manufacturers of the MMR vaccine.

The Wall St Journal and many other news outlets have reported that Stephen A. Krahling and Joan A. Wlochowski, former Merck virologists, filed a lawsuit in 2010, accusing the drug maker of falsifying data about its mumps vaccine. The case has not yet been settled nine years later and the virologists complain that the company is not making some documents available to the court.

Single vaccines are used privately in Britain

Although separate vaccines for measles, mumps and rubella are now unlicensed in Britain, it is not illegal for doctors and clinics to import the vaccines as long as they inform the Medicines Control Agency (MCA) that they are bringing the vaccine into the country.

Dr Richard Halvorsen, a GP with over 20 years’ experience and the author of OK Vaccines: Making the Right Choice for Your Child (2017), has written widely on the subject. He runs an immunisation service in Britain that offers parents a choice of buying single and small combination vaccines which includes the single measles and measles/rubella vaccines.

Should not all parents have the right to request the single vaccines for measles, mumps and rubella under the NHS system?

 

 

 

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Medic’s warning: prescribed medication caused a 50% increase in emergency admissions & nearly 100,000 hospitalisations a year in England

10 Feb

 

An article by Dr Mark Porter (December 2018) opens, “The first thing I do when faced with a poorly patient is to look at their medication to see if it could be responsible. You would be surprised how often it is”. Polypharmacy is rife: 1 in 18 of the population is taking ten medicines or more and potent pharmaceuticals carry risks as well as benefits. Millions of people are taking medication such as blood pressure pills and statins to prevent problems they may never have.

The really important message that reducing your risk of heart disease is best done by an improved diet and lifestyle is getting ‘crowded out’

Repeated campaigns have advocated mass medication – for example the February 2014 drive by the National Institute for Health and Care Excellence (the ‘health watchdog’) saying that the vast majority of men aged over 50 and most women over the age of 60 should take the drugs to guard against strokes and heart disease – though studies have suggested that up to one in five patients taking statins suffers some kind of ill-effect, including muscle aches, memory disturbance, cataracts and diabetes.

The Times reported on February 1st that a study published in the Lancet says all men over 60 and women over 75 are at high enough risk of cardiovascular problems to be eligible for the drugs. Professor Colin Baigent from Oxford University, a ‘co-investigator’, says “The risk of heart attacks and strokes increases markedly with age, and yet statins are not utilised as widely in older people as they should be”.

Dr Porter writes: “it is not illegal drug use in older people that concerns me most. I am embarrassed to report that prescribed medication exacts a far bigger toll on the nation’s health. Since 2008 there has been a 50% increase in the number of emergency admissions to hospitals for adverse drug events caused by medicines. In England alone such reactions are responsible for nearly 100,000 hospitalisations a year”.

He explains that anti-inflammatories such as ibuprofen and naproxen can work wonders for aches and pains from arthritic joints, but they have worrying side-effects and don’t mix well with many drugs commonly prescribed to treat high blood pressure (BP). They can damage the lining of the stomach, causing life-threatening bleeds (responsible for thousands of admissions every year) and can lead to kidney failure (on their own and when taken with BP drugs).

More subtle reactions impairing the quality of life are far more common and much easier to miss. Dr Porter gives a few examples from an ‘endless list’:

  • Blood pressure and heart pills that cause coughs (e.g. ramipril) and erectile dysfunction.
  • The prostate drug tamsulosin that can make you light-headed and increase the risk of falling.
  • Statins that cause aches and pains and reduce mobility.
  • Sleeping tablets that lead to addiction.
  • Cramp pills (quinine) that can cause heart problems.

He gave a striking case history:

“An elderly man with “early dementia” and diabetes was admitted to a residential home on our patch, where the staff reported that their new resident just sat in the corner all day looking vacant. His drug chart revealed he was taking an old-fashioned treatment for diabetes (gliclazide) that was pushing his blood sugars too low. It was stopped and two weeks later he was a new man and back in his own home. It is a lesson I have never forgotten”.

In October, an analysis in the British Medical Journal cautioned against any expansion in prescribing. One of its authors, Dr John D Abramson, clinical lecturer in primary care, from Harvard Medical School, last night said: “I think we have become victims of the drug companies. All the research is funded by them, and the really important message – that reducing your risk of heart disease is best done by an improved diet and lifestyle – is getting crowded out.”

 

 

 

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Mass-medication 3: is compulsory fortification of all flour with folic acid imminent?

17 Oct

The Guardian reports that senior government sources say compulsory fortification of all flour with folic acid will be introduced within weeks.  

Theresa May, who was opposed to the measure, has been persuaded to back a plan to add folate supplement to food after a campaign to reduce the number of babies born in the UK with the neural tube defect (NTD). The Independent adds that the Department of Health and Social Care said the proposal is still being considered.

Two years ago, when the second reading of the above bill was debated, Lord Prior quoted from a report by the UK government’s Scientific Advisory Committee on Nutrition (SACN):

“The fortification of white bread flour with folic acid should be introduced only if it is accompanied by a number of preconditions: for example, action to reduce folic acid intakes from voluntary fortified foods, to ensure that individuals do not substantially exceed their safe maximum daily intake of folic acid . . . It also told us that there is inconclusive evidence on several possible adverse health effects of the mandatory fortification of flour with folic acid. For example, for people aged 65 and over, folate fortification of flour may result in cases of vitamin B12 deficiency not being diagnosed and treated”.

Clinical Education reports that Dr Edward Reynolds from King’s College, London has researched this matter, reviewing the literature from the 1940’s. He maintains that the recommended current upper limit of folate -1 mg – is too high.

In the 2016 debate, however, Lord Prior said the dangers of over-medication are small: “The issue is one of balancing the scientific and medical arguments with issues around choice and whether or not it is right to medicate the entire population for the benefit of a fairly small part of it”.

All women are recommended by the NHS to take a daily supplement of 400 micrograms of folic acid while they’re trying to get pregnant and during the first 12 weeks of pregnancy, when the baby’s spine is developing. The BDA asserts that very few women take this advice and according to research published in a 2015 paper in the British Medical Journal, the prevalence of NTD pregnancies was 1.28 per 1000 total births.

A reader comments on the Independent article: “70 million people to be mass-medicated for the sake of 1000 women… well that makes sense doesn’t it?”

 

 

 

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Mass-medication 2: the prevention element – a potential revenue stream?

23 Sep

As Andrew Miles, senior UK vice-president of GlaxoSmithKline observed cryptically in the Financial Times recently, “As much as people might think that the prevention element may not be a revenue stream for the company, it provides phenomenal insights.”

In July, the journal Science Translational Medicine published a report of the trial at Novartis Institutes for Biomedical Research in Massachusetts into a treatment, administered as two daily pills. A Times article noted that it was found to cut the number of infections in older people. Stephen Evans, the professor of pharmacoepidemiology at the London School of Hygiene and Tropical Medicine, said that the study was only an incremental improvement on the treatments already available and there are unanswered questions about the possible side-effects of the drugs.

Mass medication is an iatrogenic catastrophe

In June, this view was expressed in a BMJ article by James Le Fanu, retired GP and journalist. He wrote that ‘profligate’ prescribing has brought a hidden epidemic of side effects and no benefit to most individuals. There is no drug or procedure with its “chance of good” that may not harm some. The more doctors do, the greater that risk. Over the past 20 years there has been:

  • a dizzying fourfold rise in prescriptions for diabetes treatments,
  • sevenfold for antihypertensives,
  • and 20-fold for the cholesterol lowering statins.
  • Meanwhile the number of people taking five or more different drugs has quadrupled to include almost half of those aged 65 or over.

He continues: “The consequences of this massive upswing in prescribing? A hidden epidemic of immiserating symptoms such as fatigue, muscular aches and pains, insomnia, and general decrepitude, a 75% rise in emergency admissions to hospital for adverse drug reactions (an additional 30 000 a year) …

Proposals have been made in the past for mass or even universal medication by aspirin and statins

The NHS now concludes that the risk of side effects (particularly the risk of bleeding) outweighs the benefit of preventing blood clots. It has long been known that the pills carry a risk of gastro-intestinal bleeding. But a new University of Oxford study, published in The Lancet, suggests that the danger increases far more sharply with age than was thought, according to Professor Peter Rothwell, lead author. A Telegraph artlcle reports on his 2017 findings, adding that taking a daily aspirin is more dangerous than was thought, causing more than 3,000 deaths a year.

Britain is already the “statins capital” of Europe

The UK has the second highest prescribing levels in the Western world, with aggressive prescribing of the medication by GPs, whose pay is linked to take-up of the pills.

In 2014 it was reported that twelve million people (one in four adults) would be told to take statins under controversial new NHS guidelines. Draft proposals from health watchdogs were that the vast majority of men aged over 50 and most women over the age of 60 are likely to be advised to take the drugs to guard against strokes and heart disease. The National Institute for Health and Care Excellence (Nice) had cut the “risk threshold” for such drugs in half and experts said that the number of patients advised to take the drugs is likely to rise from seven million to 12 million.

And current medical guidance says that anyone with a 20% risk of developing cardiovascular disease within 10 years should be offered statins.

Almost all men over 60 and all women over 75 in England qualify for statin prescriptions under guidelines adopted by the National Institute for Health and Care Excellence in 2014, a 2017analysis shows – see BMJ.

However, some health experts have questioned the industry forces behind these studies. The first recommendation was put out in 2013 by the American College of Cardiology (ACC) and the American Heart Association (AHA).  CNN reports that a number of experts who worked on the ACC/AHA guidelines had financial links to drug companies, which they disclosed publicly. No conflicts of interests were reported by the authors of the United States Preventive Services Task Force guidelines, but nearly all of the trials they included in their analysis were sponsored by industry, according to Dr Rita Redberg, who stressed this point in a January 2017 editorial in the journal she oversees. “The ACC did not follow its own conflict of interest guidelines“..

Fluoridation – or any practice that uses the public water supply as a vehicle to deliver medicine – violates medical ethics in several important ways:

  • It deprives the individual of his or her right to informed consent to medication.
  • It is approved and delivered by people without medical qualifications.
  • It is delivered to everyone regardless of age, health or nutritional status, without individual oversight by a doctor and without control of dose.
  • The safety of fluoridated water has never been demonstrated by randomized controlled trials–the gold standard study now generally required before a drug can enter the market.

Fluoridating water is a form of mass medication and most western European nations have rejected the practice — because, in their view, the public water supply is not an appropriate place to be adding drugs.

Who profits from all these instances of largescale medication?

 

 

 

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