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Pesticide use: the tide appears to be turning

14 May

Bayer, the German company which bought the US agrochemical firm Monsanto, acquired its lucrative portfolio of pesticides and genetically modified seeds – and more than 13,000 pending cases relating to glyphosate sold under the brand name Roundup. At its annual meeting in Bonn last month, in an unprecedented revolt, more than 55% of shareholders declared they had no confidence in management. The ongoing fall in its share prices has accelerated. (Reuters 14.5.19).

Prof. Ian Boyd, chief scientific adviser to the UK government points out that regulators around the world have falsely assumed it is safe to use pesticides at industrial scales across landscapes, that other research in 2017 showed farmers could slash their pesticide use without losses and quoted a UNGA report denouncing the “myth” that pesticides are necessary to feed the world.

Recent reports in the BMJ, the International Journal of Epidemiology and the European Food Safety Authority, add weight to Professor Boyd’s stance

Prenatal and infant exposure to ambient pesticides and autism spectrum disorder in children: population based case-control study, BMJ, 20 March 2019 (open access) notes that common pesticides have been previously shown to cause neurodevelopmental impairment in experimental research and environmental exposures during early brain development are suspected to increase risk of autism spectrum disorders in children. The study’s findings suggest that an offspring’s risk of autism spectrum disorder increases following prenatal exposure to ambient pesticides (including glyphosate, chlorpyrifos, diazinon, and permethrin) within 2000 m of their mother’s residence during pregnancy, compared with offspring of women from the same agricultural region without such exposure. Infant exposure could further increase risks for autism spectrum disorder with comorbid intellectual disability.

• In February, researchers at the University of Washington (UW) published a new scientific analysis of glyphosate (PDF) (right), the active ingredient in Monsanto-owned Bayer’s Roundup, the world’s most popular weedkiller. They concluded that evidence supports a “compelling link” between glyphosate and non-Hodgkin lymphoma (NHL), a type of blood cancer.
• Glyphosate exposure increases cancer risk up to 41% according to a study published in the IInternational Journal of Epidemiology (March). Observations in this analysis of >300 000 farmers and agricultural workers from France, Norway, and the USA, included elevations in risks of non-Hodgkin lymphoid malignancies (NHL) overall in association with the organophosphate insecticide terbufos, of chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) with the pyrethroid insecticide deltamethrin and of diffuse large B-cell lymphoma (DLBCL) with the organophosphorus herbicide glyphosate.

• More transparency sought: an EU court ruled on 7 March that the EU Food Safety Authority (EFSA) should publicise studies about Monsanto’s glyphosate weedkiller. The General Court’s statement said that it annulled decisions by the EU food watch agency “refusing access to the toxicity and carcinogenicity studies on the active substance glyphosate”.

• On March 29th – after safety officials reported human health and environmental concerns – EU states voted for a ban of chlorothalonil, a fungicide, after a review by the European Food Safety Authority was unable to exclude the possibility its breakdown products, cause damage to DNA. EFSA also said “a high risk to amphibians and fish was identified for all representative uses”. Recent research further identified chlorothalonil and other fungicides as the strongest factor linked to steep declines in bumblebees.

Reuters reports that a California jury found on Monday that Monsanto’s Roundup likely caused a couple’s cancer and awarded them a staggering $2.055 billion in damages, in a third consecutive Roundup trial loss for the Bayer-owned unit. In one trial last August, a US court in California awarded damages and costs against Monsanto to 46-year-old park worker Dewayne Johnson, who was diagnosed with cancer after using the chemical.

But there’s still way to go; Monsanto – apparently undaunted – offers another  product, said to have less damage potential

Monsanto is reformulating its dicamba pesticide which tended to drift and earlier damaged millions of acres of crops and wild trees in 2017.

Farmers in 25 states had submitted more than 2,700 claims to state agricultural agencies that year and it was banned in the state of Arkansas last year, where almost 900,000 acres of crop damage (above) were reported. Monsanto unsuccessfully sued the state in an effort to stop the ban.

A lower volatility formulation, M1768, ‘a product with less potential to volatilize and move off the target area’ has been approved by the EPA for use until 2020 – on corn, wheat, cotton, soybeans and other crops – though it has not been evaluated by experts independent of Monsanto. It was obliged by the American government’s Environmental Protection Agency to agree to registration and labelling changes for the 2018 growing season, including making these products restricted-use and requiring record-keeping and additional measures to prevent spray drift.

 

 

 

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Weigh the value of new ‘tools’; apply the precautionary principle

3 Jun

There is mounting evidence of unintended harmful consequences in many sectors – including medicine, pharmacology, agriculture, energy generation, finance, engineering and transport. The most widely read post on this site in May reported the Lancet’s publication of the World Health Organisation’s finding that glyphosate, a widely used ingredient in weedkiller, is probably carcinogenic.

Michael J. Coren‘s article in Quartz magazine summarised the findings of Jameson Wetmore, an engineer turned social researcher at the Arizona State University’s School for the Future of Innovation in Society. Wetmore opened:

“The motto of the 1933 World Fair in Chicago was “Science Finds, Industry Applies, Man Conforms. Governments and companies were saying that technology can lead us out of this. It may not always be comfortable, but we have to ride it out. Household technologies were all the rage. When you hit the 1960s and 1970s, there is this shift.

“I think the hallmarks of that shift are the dropping of the atomic bomb, and then of course you have Ralph Nader’s Unsafe at Any Speed, and you also have Rachel Carson’s Silent Spring”.

“Whereas much of the contemporary world sees technological progress as inevitable, even a moral imperative, Wetmore finds that the Amish watch their neighbours and carefully consider how each one will change their culture before embracing it: They . . . watch what happens when we adopt new technology, and then they decide whether that’s something they want to adopt themselves.”

We don’t think about the impact technology might have on our lives beyond the initial big idea.

“The automobile was sold to us with this idea of a freedom we never had before. With that freedom came a heavy toll of injury and death. So can we anticipate unintended consequences way the Amish do, or are these systems just too complex to go much beyond first-order effects?

A more rigorous application of the EU’s Article 191 (left) would help to do this.

“Less than a mile from where I’m standing [in Phoenix, Arizona], Elaine Herzberg was killed by an autonomous Uber vehicle. I fully recognize the only way we’re going to automated vehicles is running in this world is to test them on city streets. Now, if we were to sit back and think about the values of the society here, we might say that testing those vehicles at 10 PM at night outside of a concert hall where a huge amount of alcohol had been served was not the best place to be testing. Perhaps testing in a school zone when children are present is not the best place to test an autonomous vehicle. But those are decisions that local people did not have the chance to make.”

The idea that technology is an unmitigated good is beginning to be questioned

Wetmore thinks that today Americans have a much more nuanced view of things. The number of people who think technology is an unmitigated good is continuing to shrink, but most haven’t abandoned the idea that there are a lot of problems and technology will play a role in solving them.

The precautionary principle detailed in Article 191 of the Treaty on the Functioning of the European Union aims at ensuring a higher level of environmental protection through preventative decision-taking in the case of risk. It also covers consumer policy, European Union (EU) legislation concerning food, human, animal and plant health. It has been recognised by various international agreements, notably in the Sanitary and Phytosanitary Agreement (SPS) concluded in the framework of the World Trade Organisation (WTO).  

Jeremy Corbyn led the proposal (right) to retain Article 191’s environmental principles after exit day, narrowly defeated by 16 votes.

 

Time for change?

 

 

 

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RSM conference: Fera Science data finds toxic cocktails of pesticides – a public health hazard

26 Jan

Many readers will have noted that, in November, speaking at a Royal Society of Medicine conference on pesticides, scientists warned that consuming tiny amounts of many different chemicals on a regular basis could be harmful to human health.

The conference heard new scientific evidence from around the world showing that very low doses of pesticides, well below official ‘safety’ levels, pose a significant risk to public health from pesticides in the food supply.

More pesticides and herbicides are now used on crops because weeds and insects have become increasingly resistant to chemicals. See University of California document (insect resistance, frost paragraph).

Dr Michael Antoniou (left, head of the gene expression and therapy research group at King’s College London) said that all the evidence shows that people should minimise their exposure to pesticides.

Prof Anne Marie Vinggaard (division of diet, disease prevention and toxicology at the Danish National Food Institute) said “We are not just exposed to pesticides. We are exposed to a lot of chemicals acting together Consumption of “toxic cocktails” of low levels of pesticide cocktails are thought to be linked with degenerative diseases like strokes, heart attacks and cancers”.

Katie Morley, the Telegraph’s Consumer Affairs Editor, reports that figures released by the Soil Association, which certifies organic food, show that the number of toxic chemicals found in onions, leeks, wheat and potatoes has been steadily increasing since the 1960s, though industry data shows that the volume of pesticides found on supermarket vegetables has halved since the 1990s. Onions and leeks have seen the biggest rise in toxic chemicals. In 1974 less than two chemicals were applied to an average wheat crop.

The figures were compiled by data firm Fera Science, formerly the government’s Food and Environment Research Agency and now 75% owned by Capita and 25% by the Department for Environment, Food and Rural Affairs who hold UK Government data on pesticide use in farming. The research found that pesticide active ingredients applied to three British crops have increased between 6 and 18 times ranging from 480% to 1,700% over the last 40-odd years.

Dr Antoniou’s advice: “Minimally as a precaution you should minimise your exposure to pesticides. The only way to guarantee that, is by eating organically”

 

 

 

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Roundup glyphosate: risk of cancer to ‘exposed’ agricultural workers and gardeners

7 Dec

A huge mistake? The European Commission will formalise on 12 December Monday’s decision by member states to renew for five years the licence for the herbicide glyphosate.

Weasel words in the FT last week:

“Although the World Health Organization last year said the herbicide was “probably carcinogenic”, the latest joint assessment by UN agencies concludes there is no risk to humans from exposure through the diet” – implying that evidence shows that the use of the herbicide is risk free.

In May last year, the UN agencies said:

“The overall weight of evidence indicates that administration of glyphosate and its formulation products at doses as high as 2000 mg/kg body weight by the oral route, the route most relevant to human dietary exposure, was not associated with genotoxic effects in an overwhelming majority of studies conducted in mammals, a model considered to be appropriate for assessing genotoxic risks to humans. The meeting concluded that glyphosate is unlikely to be genotoxic at anticipated dietary exposures” (emphasis added).

Dr Christopher Connolly, a reader in neurobiology at the University of Dundee, said in an article in the Science Media Centre journal: “The evidence on the risk to human health from glyphosate is highly controversial, making it difficult for politicians to make a sound science-based decision. It is alarming that it is so ubiquitous that it is found commonly in human urine. We must make the next five years count, so that an evidence-based decision may be made at the end of this period.

Prof. David Coggon, Professor of Occupational and Environmental Medicine at the University of Southampton, said:

“IARC classified glyphosate as probably having the potential to cause cancer in humans. This was based on evidence of carcinogenicity in animals and suggestions of an association with lymphoma in exposed people (mainly agricultural workers, landscapers, nursery workers and home gardeners).

Cancer incidence among glyphosate-exposed pesticide applicators in the Agricultural Health Study (2005)

Summary:

We evaluated associations between glyphosate exposure and cancer incidence in the Agricultural Health Study (AHS), a prospective cohort study of 57,311 licensed pesticide applicators in Iowa and North Carolina. There was a suggested association with multiple myeloma incidence (a type of bone marrow cancer) that should be followed up as more cases occur in the AHS. Given the widespread use of glyphosate, future analyses of the AHS will allow further examination of long-term health effects, including less common cancers.

The World Health Organization’s International Agency for Research on Cancer in March 2015 said that glyphosate is “probably carcinogenic to humans” (PDF), adding “The evidence in humans is from studies of exposures, mostly agricultural, in the USA, Canada, and Sweden published since 2001”.

The latest news was reported by CNN in May this year, opening with story of Christine Sheppard

For 12 years, she had no idea what might have caused her non-Hodgkin’s lymphoma — until the IARC reported that glyphosate, the key ingredient in the weed killer Roundup, is probably carcinogenic. Roundup is the herbicide she sprayed on her coffee farm in Hawaii for five years.

That report spurred hundreds of non-Hodgkin’s lymphoma patients to sue Monsanto. Timothy Litzenburg’s law firm represents more than 500 of them. He said most of the patients didn’t know about a possible link between Roundup and non-Hodgkin’s lymphoma until the report came out.

Other companies also sell products containing glyphosate, why target Monsanto?

Litzenburg points out that Monsanto invented Roundup, they held the patent for many years, they are the EPA registrant for glyphosate, and they continue to dominate the market, adding:

“We are not alleging that our clients got cancer from glyphosate alone. We are suing because our clients got cancer from Roundup. … Roundup contains animal fats and other ingredients that increase the carcinogenicity of the glyphosate.”

Though UN agencies concluded that as yet no risk to humans from exposure through diet has been found, studies find that workers and gardeners using Roundup risk contracting non-Hodgkin’s lymphoma and multiple myeloma (a type of bone marrow cancer) – surely sufficient reason to withdraw the herbicide from use.

Media reports, including by EUobserver and Dutch magazine OneWorld, have shown that Efsa conclusions on the safety of glyphosate were partially based on scientific evidence provided by Monsanto, Roundup’s manufacturer. On 19 October, also the European Parliament expressed doubts over the scientific evaluations of glyphosate carried out by the European agencies.

Despite these findings, the European Commission will formalise on 12 December a decision by member states to renew the licence for the herbicide glyphosate for five years: https://euobserver.com/environment/140065.

Will Brexit give people in this country the opportunity to denounce the use of this and other dangerous substances and technologies and bring about beneficial change?

 

 

 

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GM news escalates: ‘whitewashing’ glyphosate, Monsanto papers, Michael Gove persuadable?

12 Nov

Der Spiegel reports that a court in San Francisco ordered U.S. agrochemical giant Monsanto to provide internal emails as evidence after about 2,000 plaintiffs demanded compensation from Monsanto in class-action suits. They claim that Roundup has caused non-Hodgkin’s lymphoma, a form of lymph node cancer, in them or members of their family.

More than 100 documents have revealed that Monsanto’s strategies for ‘whitewashing glyphosate’ have been revealed in internal e-mails, presentations and memos. They suggest the company concealed risks, making their publication a disaster for the company. The matter is also likely to be a topic of discussion at Bayer, the German chemical company in the process of acquiring Monsanto.

“The Monsanto Papers tell an alarming story of ghostwriting, scientific manipulation and the withholding of information,” says Michael Baum, a partner in the law firm of Baum, Hedlund, Aristei & Goldman, which is bringing one of the US class actions. According to Baum, Monsanto used the same strategies as the tobacco industry: “creating doubt, attacking people, doing ghostwriting.”

On October 11th, the European Parliament’s Environment and Agriculture committee held a public hearing on The Monsanto Papers. 

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Despite this, the BBC reports that an EU vote has failed to resolve a controversy over the use of glyphosate, the world’s biggest-selling weedkiller. Glyphosate was introduced by US agrochemical giant Monsanto in 1974, but its patent expired in 2000, and now the chemical is sold by various manufacturers.

The European Commission said the vote fell short of the majority needed to renew the license for five years when it expires December 15, as only half of the 28 member states voted for its proposal. “Given that a qualified majority could not be reached … the result of the vote is ‘no opinion,'” said the commission, the EU’s executive and regulatory arm. An EU appeal committee will now try to rule on the issue. A qualified majority requires that 55% of EU countries vote in favour, and that the proposal is supported by countries representing at least 65% of the total EU population.

The UK was among the 14 states backing the Commission position on glyphosate. Nine voted against – including France and Italy. Germany was among the five who abstained.

But a reader sends the information that the environment secretary, Michael Gove, now says the UK will back a total ban on insect-harming pesticides in fields across Europe . . . Perhaps he can be persuaded to ban human-harming, resistance-forming glyphosate as well.

Is the balance of nature being adversely affected by pesticides?

12 Oct

In May this year, Horticulture Weekly and other sources reported that most ‘insect-friendly’ plants sold in garden centres and supermarkets are laced with chemicals that could be killing bees.

More than 70% of ‘pollinator-friendly’ specimens from B&Q, Homebase, Aldi & Wyevale, studied by scientists at Sussex University led by Professor Dave Goulson, tested positive for pesticides after screening pollen, nectar and leaves. One type of heather bought from the Wyevale chain contained five insecticides as well as five fungicides. Every retailer sold plants containing the EU 2013 ‘banned’ neonicotinoids (imidacloprid, thiamethoxam or clothianidin.

Quartz updates us: reporting that a study published on Oct. 6 in the journal Science found that a significant amount of the world’s honey contains traces of neonicotinoids,, a class of commonly used pesticides, at levels strong enough to cause brain damage in bees – but not (yet?). human beings.The chemicals are meant to attack the nervous systems of pests and keep them from eating crops.

American environmentalists have expressed concern, since president Donald Trump appointed Scott Pruitt – who has prioritised business interests – to head the US Environmental Protection Agency.

In the past, Pruitt, who has been described by some as being especially friendly with pesticide manufacturers and an ‘ally’ of the fossil fuel industries, has vigorously opposed environmentally beneficial legislation.

What will be the long-term effects of bees, birds,  bats and frogs, butterflies, houseflies, crane flies and other insects dying from chemical pollution?

 

 

Out in the open: Monsanto’s involvement in the retraction of the Séralini paper

22 Sep

Claire Robinson reports that internal Monsanto documents released by attorneys leading US cancer litigation show that Monsanto attempted to suppress a study showing adverse effects of Roundup herbicide. The full report may be read here.

She writes: “The study, led by Prof GE Séralini, showed that very low doses of Monsanto’s Roundup herbicide had toxic effects on rats over a long-term period, including serious liver and kidney damage. Additional observations of increased tumour rates in treated rats would need to be confirmed in a larger-scale carcinogenicity study”.

The New York Times has published some of the emails mentioned by Claire. In the documents released by the American law firm, Monsanto scientist David Saltmiras admitted orchestrating a “third party expert” campaign in which scientists who were apparently independent of Monsanto would bombard the editor-in-chief of the journal Food and Chemical Toxicology (FCT), A. Wallace Hayes, with letters demanding that he retract the study. In one document, Saltmiras reviews his own achievements within the company, successfully facilitating numerous third party expert letters to the editor which were subsequently published, alleging numerous significant deficiencies, poor study design, biased reporting and selective statistics employed by Séralini. Another Monsanto employee, Eric Sachswrites in an email about his efforts to galvanize scientists in the letter-writing campaign.

Sachs refers to Bruce Chassy, a scientist who runs the pro-GMO Academics Review website (and has ‘form’)

Sachs writes: “I talked to Bruce Chassy and he will send his letter to Wally Hayes directly and notify other scientists that have sent letters to do the same. He understands the urgency… I remain adamant that Monsanto must not be put in the position of providing the critical analysis that leads the editors to retract the paper.”   Chassy (left)was the first signatory of a petition demanding the retraction of the Séralini study and the co-author of a Forbes article accusing Séralini of fraud. In neither document does Chassy declare any link with Monsanto. But in 2016 he was reported to have taken over $57,000 over less than two years from Monsanto to travel, write and speak about GMOs.

The disclosed documents show that the editor of Food and Chemical Toxicology, A. Wallace Hayes, entered into a consulting agreement with Monsanto in the period just before Hayes’s involvement in the retraction of the Séralini study.

Clearly there was a conflict of interest between Hayes’ role as a consultant for Monsanto and his role as editor for a journal that retracted a study determining that glyphosate has toxic effects. The study was published on 19 September 2012; the consulting agreement between Hayes and Monsanto was dated 21 August 2012 and Hayes is contracted to provide his services beginning 7 September 2012.

A Monsanto internal email confirms the company’s intimate relationship with Hayes (right). Saltmiras writes about the recently published Séralini study: “Wally Hayes, now FCT Editor in Chief for Vision and Strategy, sent me a courtesy email early this morning. Hopefully the two of us will have a follow up discussion soon to touch on whether FCT Vision and Strategy were front and center for this one passing through the peer review process.” Monsanto got its way, though the paper was subsequently republished by another journal with higher principles – and, presumably, with an editorial board that wasn’t under contract with Monsanto.

Some regulatory bodies have backed Monsanto rather than the public interest. In fact, the EU is considering dispensing with the short 90-day animal feeding studies currently required under European GMO legislation.

Now that Monsanto’s involvement in the retraction of the Séralini paper is out in the open, FCT and Hayes should issue a formal apology to Prof Séralini and his team. FCT cannot and should not reinstate the paper because it has been published by another journal. But it needs to draw a line under this episode, admit that it handled it badly, and declare its support for scientific independence and objectivity.

 

 

 

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